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Mycotoxin
Mycotoxin found in cereals. Binds to the ribosome and inhibits protein synthesis.
Emetic and refusal activity in pig.
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Product Details
| Alternative Name |
DON, 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin |
|---|---|
| Appearance |
White to off-white powder. |
| CAS |
51481-10-8 |
| Formula |
C15H20O6 |
| MI |
14: 10032 |
| MW |
296.3 |
| Purity |
≥98% (TLC, HPLC) |
| RTECS |
YD0167000 |
| Solubility |
Soluble in methanol or ethyl acetate; slightly soluble in water. |
| Source |
Isolated from Fusarium sp. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
+4°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2: A.K. Diesing, et al.; Toxicol. Lett. 200, 8 (2011), Abstract
- Ribotoxic mycotoxin deoxynivalenol induces G(2)/M cell cycle arrest via p21(Cip/WAF1) mRNA stabilization in human epithelial cells: H. Yang, et al.; Toxicology 243, 145 (2008), Abstract
- Some major mycotoxins and their mycotoxicoses–an overview: J.L. Richard; Int. J. Food Microbiol. 119, 3 (2007), (Review), Abstract
- Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture: M. Königs, et al.; Toxicology 240, 48 (2007), Abstract
- The effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan adsorbent on lactation, serum chemistry, and reproductive performance after weaning of first-parity lactating sows: G. Diaz-Llano & T.K. Smith; J. Anim. Sci. 85, 1412 (2007), Abstract
- Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages: Q. Jia, et al.; J. Nutr. 136, 366 (2006), Abstract — Full Text
- Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations: T. Sergent, et al.; Toxicol. Lett. 164, 167 (2006), Abstract
- Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes: T. Goyarts, et al.; Toxicol. In Vitro 20, 858 (2006), Abstract
- Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum: N. Ponts, et al.; FEMS Microbiol. Lett. 258, 102 (2006), Abstract
- Detection of deoxynivalenol in foods and indoor air using an array biosensor: M.M. Ngundi, et al.; Environ. Sci. Technol. 40, 2352 (2006), Abstract
- Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants: J. Pestka & H.R. Zhou; Toxicol. Sci. 92, 445 (2006), Abstract — Full Text
- Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens: W.A. Awad, et al.; J. Anim. Physiol. Anim. Nutr. (Berl) 90, 32 (2006), Abstract
- The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for Fusarium head blight resistance in wheat: M. Lemmens, et al.; Mol. Plant Microbe Interact. 18, 1318 (2005), Abstract
- Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice: M.E. Gouze, et al.; Cell. Mol. Biol. (Noisy-le-grand) 51, OL809 (2005), Abstract
- Simultaneous detection of several Fusarium mycotoxins in cereals, grains, and foodstuffs: H. Kamimura, et al.; J. Assoc. Off. Anal. Chem. 64, 1067 (1981), Abstract
- Emetic and refusal activity of deoxynivalenol to swine: D.M. Forsyth, et al.; Appl. Environ. Microbiol. 34, 547 (1977), Abstract — Full Text
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