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Deoxymannojirimycin . HCl

BML-S109

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Mannosidase inhibitor

Potent inhibitor of α-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. Induces ER stress in human cells.

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Product Details

Appearance	White solid.
CAS	73465-43-7
Couple Target	Mannosidase
Couple Type	Inhibitor
Formula	C₆H₁₃NO₄ . HCl
Identity	Determined by 1H-NMR.
MW	199.6
Purity	≥98% (TLC)
Solubility	Soluble in water, methanol (warm) and DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells: Nacev, B. A., Grassi, P., et al.; J. Biol. Chem. 286, 44045 (2011), Abstract
1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721: Y. Lu et al.; Biochem. Biophys. Res. Commun. 344, 221 (2006), Abstract
Effect of retinyl acetate on the assembly of the fibronectin extracellular matrix and the processing of the fibronectin receptor beta subunit of confluent C3H/10T1/2 mouse embryo fibroblasts: S.S. Suzuki & L.H. Piette; J. Cell. Biochem. 51, 181 (1993), Abstract
The use of 1-deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells: J. Bischoff et al.; J. Biol. Chem. 261, 4766 (1986), Abstract
Inhibitors of oligosaccharide processing: U. Furhmann et al.; Biochim. Biophys. Acta 825, 95 (1985), Abstract
Secretion of high-mannose-type alpha 1-proteinase inhibitor and alpha 1-acid glycoprotein by primary cultures of rat hepatocytes in the presence of the mannosidase I inhibitor 1-deoxymannojirimycin: V. Gross et al.; Eur. J. Biochem. 150, 41 (1985), Abstract

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Deoxymannojirimycin . HCl

BML-S109

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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