Deguelin

ALX-350-118

Datasheet
Manual
SDS
CofA

Already have an account?

COX-2 inhibitor

Inhibitor of Akt (protein kinase B; PKB) in an in vitro lung carcinogenesis progression model. Inhibits cell proliferation – cells accumulate in the G2-M phase of the cell cycle. Premalignant and malignant human brochial epithelial cells are highly sensitive to deguelin compared to normal cells. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	[-]-Deguelin
Appearance	White to yellow powder.
CAS	522-17-8
Couple Target	COX
Couple Type	Inhibitor
Formula	C₂₃H₂₂O₆
MI	14: 2863
MW	394.4
Purity	≥95% (HPLC)
RTECS	DX1500000
Solubility	Soluble in acetone, acetonitrile, DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat: Paulus, P., Ockelmann, P., et al.; PLoS One 7, e39265 (2012), Abstract
IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter: Mitchell, G. C., Fillinger, J. L., et al.; Cell Death Dis. 1, e50 (2011), Abstract
Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata: C. Ito, et al.; Planta Med. 70, 8 (2004), Abstract
Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.: N. Hail, et al.; Apoptosis 9, 437 (2004), Abstract
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells: H.Y. Lee, et al.; Clin. Cancer Res. 10, 1074 (2004), Abstract
Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells: H.Y. Lee; Biochem. Pharmacol. 68, 1119 (2004), Abstract
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells: K.H. Chun, et al.; J. Natl. Cancer Inst. 95, 291 (2003), Abstract — Full Text
Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest: G. Murillo, et al.; Eur. J. Cancer 38, 2446 (2002), Abstract
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid: G.O. Udeani, et al.; Cancer. Res. 57, 3424 (1997), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Deguelin

ALX-350-118

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project