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Decylubiquinone

BML-CM115

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MPTP inhibitor

MPTP inhibitor used in cellular metabolism studies

Decylubiquinone is an analogue of ubiquinone. Decylubiquinone inhibits the Ca²⁺-dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration. Maximum effect on Ca²⁺ retention capacity of rat liver mitochondria can be achieved with decylubiquinone at 100μM. This inhibitory effect of decylubiquinone on MPTP can be counteracted by ubiquinone-5 (Prod. No. ALX-270-294). Decylubiquinone also inhibits etoposide-induced apoptosis in in L929 cells at 5μM.

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Product Details

Alternative Name	2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
Appearance	Neat yellow to orange colored oil.
CAS	55486-00-5
Couple Target	MPTP
Couple Type	Inhibitor
Formula	C₁₉H₃₀O₄
MW	322.4
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mitochondrial complex III activity: from invasive muscle biopsies to patient-friendly buccal swab analysis: Somers, T., Allard, N. A. E., et al.; Sci. Rep. 13, 9638 (2023), Abstract
Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice: T.J. Schirris, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1867, 166062 (2021), Abstract
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism: M.G. Acoba, et al.; Cell Rep. 34, 108869 (2021), Abstract — Full Text
Disruption of acetyl-lysine turnover in muscle mitochondria promotes insulin resistance and redox stress without overt respiratory dysfunction: A. Williams, et al.; Cell Metab. 31, 131 (2019), Abstract — Full Text
X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation: M. Jackson, et al.; Structure 27, 794 (2019), Abstract — Full Text
The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c: N.O. Karpinich, et al.; J. Biol. Chem. 277, 16547 (2002), Abstract — Full Text
A ubiquinone-binding site regulates the mitochondrial permeability transition pore: E. Fontaine, et al.; J. Biol. Chem. 273, 25734 (1998), Abstract — Full Text