Decitabine

• GMP format available

Decitabine works by incorporating into DNA during replication and inhibiting DNA methyltransferase, leading to DNA hypomethylation and the reactivation of silenced genes. This mechanism makes it effective in targeting rapidly dividing cancer cells, which are more susceptible to its action.

Key features and applications include:

• Epigenetic Research: Decitabine is widely used to study DNA methylation and its role in gene expression. It helps in understanding the mechanisms of gene silencing and activation.
• Cancer Research: It is used to investigate the effects of DNA hypomethylation on tumor suppressor genes and oncogenes, providing insights into cancer development and potential treatments.
• Stem Cell Research: Decitabine is employed to study the differentiation and reprogramming of stem cells, particularly in reversing the differentiation of embryonic stem cells.

Relevant disease states include:

• Myelodysplastic Syndromes (MDS): Decitabine is approved for the treatment of MDS, a group of hematopoietic disorders characterized by ineffective blood cell production.
• Acute Myeloid Leukemia (AML): It is also used in the treatment of AML, particularly in older patients who are not candidates for intensive chemotherapy.
• Chronic Myelomonocytic Leukemia (CMML): Decitabine is indicated for CMML, a type of cancer that starts in blood-forming cells of the bone marrow and invades the blood.