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Nitric oxide donor
Nitric oxide (NO) donor.
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Product Details
| Alternative Name |
DEA/NO, 2-(N,N-Diethylamino)-diazenolate-2-oxide . diethylammonium salt |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
372965-00-9 |
| Formula |
C4H10N3O2 . C4H12N |
| MW |
132.1 . 74.1 |
| Purity |
≥97% (NMR) |
| Solubility |
Soluble in 100% ethanol (25mg/ml), DMSO (2mg/ml), dimethyl formamide (2mg/ml) or PBS, pH 7.2 (10mg/ml). |
| Technical Info / Product Notes |
Dissociates to the free amine and nitric oxide in a pH-dependent manner following first order kinetics. To initiate the release of nitric oxide, add stock alkaline solution of DEA NONOate to excess buffer of pH 7.0 – 7.4. The half life in 0.1 M phosphate buffer, pH 7.4, is t½ = 16 min. at 22 -25 °C or t½= 2 min. at 37 °C. Liberates 1.5 mol of NO per mol of parent compound. Decomposition is nearly instantaneous at pH 5.0. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Store, as supplied, at-80°C for up to 1 year. Aqueous solutions should be prepared fresh daily. |
|---|---|
| Handling |
Protect from light and oxygen. Packaged under inert gas. Hygroscopic. |
| Long Term Storage |
-80°C |
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Inhibitory Peptide of Soluble Guanylyl Cyclase/Trx1 Interface Blunts the Dual Redox Signaling Functions of the Complex: Cui, C., Shu, P., et al.; Antioxidants (Basel) 12, (2023), Abstract
- The effect of short-term refrigeration on platelet responsiveness: A. Kobsar, et al.; Sci. Rep. 12, 16910 (2022), Abstract
- Influence of long-term proteasome inhibition on platelet responsiveness mediated by bortezomib: P. Klingler, et al.; Vascul. Pharmacol. 2021, 106830 (2021), Abstract
- Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism: Kline, J. A., Puskarich, M. A., et al.; Nitric Oxide 96, 20 (2020), Abstract
- AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2: K.J. Cho, et al.; Mol. Cell. Biol. 36, 3086 (2016), Abstract
- Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries: M. Barrier, et al.; Toxicol. In Vitro 32, 205 (2016), Application(s): Cell culture, Abstract
- NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1: Baig, M. S., Zaichick, S. V., et al.; J. Exp. Med. 212, 1725 (2015), Abstract
- Endogenous oestrogens do not regulate endothelial nitric oxide production in early postnatal rats: S.I. Sofronova, et al.; Eur. J. Pharmacol. 765, 598 (2015), Abstract
- Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl: M.M. Cortese-Krott, et al.; PNAS 112, e4651 (2015), Application(s): Cell culture, Abstract — Full Text
- Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation: M. Shelly, et al.; Science 327, 547 (2010), Abstract
- Effect of endogenous and exogenous nitric oxide on calcium sparks as targets for vasodilation in rat cerebral artery: M. Mandala, et al.; Nitric Oxide 16, 104 (2007), Abstract
- Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus: I.R. Fragata, et al.; Eur. J. Pharmacol. 543, 32 (2006), Abstract
- Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients: J.S. Isenberg, et al.; Free Radic. Biol. Med. 40, 1028 (2006), Abstract
- A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations: M.S. Crane, et al.; Br. J. Pharmacol. 144, 849 (2005), Abstract
- Flavin-containing monooxygenase activity can be inhibited by nitric oxide-mediated S-nitrosylation: S.D. Ryu, et al.; Life Sci. 75, 2559 (2004), Abstract
- Peroxynitrite-mediated inactivation of heme oxygenases: R. Kinobe, et al.; BMC Pharmacol. 21, 4 (2004), Abstract — Full Text
- New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
- New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
- Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects: C.M. Maragos, et al.; J. Med. Chem. 34, 3242 (1991), Abstract
- DNA deaminating ability and genotoxicity of nitric oxide and its progenitors: D.A. Wink, et al.; Science 254, 1001 (1991), Abstract
- The Reaction of Nitrogen(II) Oxide with Various Primary and Secondary Amines: R.S. Drago & B.R. Karstetter; JACS 83, 1819 (1961)
- The Reaction of Nitrogen(II) Oxide with Diethylamine: R.S. Drago & F.E. Paulik; JACS 82, 96 (1960)
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