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Damnacanthal

BML-EI274

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p56lck tyrosine kinase inhibitor

Damnacanthal is a potent and selective inhibitor of p56^lck tyrosine kinase. It inhibits p56^lck autophosphorylation (IC₅₀=17 nM) as well as phosphorylation of exogenous substrates (IC₅₀=620 nM) in cell-free assays. Damnacanthal shows a 10-fold selectivity for p56^lck over PKA and PKC and 40-fold selectivity over four receptor tyrosine kinases as well as 7–20-fold selectivity over the homologous enzymes p60^src and p59^fyn.

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Product Details

Alternative Name	3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
Appearance	Pale orange solid.
CAS	477-84-9
Couple Target	p56lck tyrosine kinase
Couple Type	Inhibitor
Formula	C₁₆H₁₀O₅
Identity	Determinedy by NMR.
MW	282.2
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity: C.R. Faltynek, et al.; Biochemistry 34, 12404 (1995), Abstract
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia: T. Hiramatsu, et al.; Cancer Lett. 73, 161 (1993), Abstract
Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum: K. Koumaglo, et al.; Planta Med. 58, 533 (1992), Abstract
Anthraquinone and anthrone series—XXIII: The non-identity of 1:3:8-trihydroxy-2-hydroxymethyl-anthraquinone with versicolorin and a synthesis of damnacanthol and damnacanthal: N.R. Ayyangar, et al.; Tetrahedron 6, 331 (1959)
Chemistry of Damnacanthus Genus. I – The Anthraquinone Coloring Matter from Damnacanthus major, D. major var. parvifolius, and D. indicus var. microphyllus. (1): S. Nonomura; Yakugaku Zasshi 75, 219 (1955), (Article in Japanese), Abstract

Last modified: May 29, 2024

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Damnacanthal

BML-EI274

Product Details

Handling & Storage

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