Home Shop D-myo-Inositol 1,4,5-trisphosphate . hexapotassium salt

D-myo-Inositol 1,4,5-trisphosphate . hexapotassium salt

ALX-307-007

10 citations

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Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.

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Product Details

Alternative Name	Ins(1,4,5)P3 . 6K, IP3
Appearance	White to off-white powder.
CAS	103476-24-0
Formula	C₆H₉O₁₅P₃ . 6K
MW	414.1 . 234.6
Purity	≥98% (TLC)
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2: Dulloo, I., Atakpa-Adaji, P., et al.; Nat. Commun. 13, 1257 (2022), Abstract
Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3: Rossi, A. M., Riley, A. M., et al.; Cell Rep. 37, 109932 (2021), Abstract
Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis: M.P. Marciel, et al.; Oncotarget 9, 13407 (2018), Abstract — Full Text
Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand: Z. Ding, et al.; Mol. Pharmacol. 77, 995 (2010), Abstract
Synthetic partial agonists reveal key steps in IP3 receptor activation: A.M. Rossi, et al.; Nat. Chem. Biol. 5, 631 (2009), Abstract — Full Text
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase: B. Gonzalez, et al.; Mol. Cell 15, 689 (2004), Abstract — Full Text
Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor: M. Auger-Messier, et al.; Mol. Endocrinol. 18, 2967 (2004), Abstract — Full Text
Inositol 1,4,5-trisphosphate-activated calcium channels: C.D. Ferris & S.H. Snyder; Annu. Rev. Physiol. 54, 469 (1992), Abstract
Inositol trisphosphate and diacylglycerol: two interacting second messengers: M.J. Berridge, et al.; Annu. Rev. Biochem. 56, 159 (1987), Abstract
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver: S.K. Joseph, et al.; J. Biol. Chem. 259, 3077 (1984), Abstract

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D-myo-Inositol 1,4,5-trisphosphate . hexapotassium salt

ALX-307-007

Product Details

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