Home Shop D-erythro-Sphingosine 1-phosphate (caged)

D-erythro-Sphingosine 1-phosphate (caged)

ALX-306-017

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A photolyzable derivative of sphingosine 1-phosphate (1-SPP) (Prod. No. BML-SL140). Important tool for the study of 1-SPP mediated intracellular events.

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Product Details

Alternative Name	1-SPP (caged)
Appearance	Clear to slight yellow oil.
Formula	C₃₄H₅₂N₃O₉P
MW	677.8
Purity	≥95%
Solubility	Soluble in methanol or 100% ethanol.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Intracellular Sphingosine-1-Phosphate Induces Lipolysis Through Direct Activation of Protein Kinase C Zeta: S. Weske, et al.; FASEB J. 39, e70528 (2025), Abstract
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1: K. Zmajkovicova, et al.; PLoS One 15, e0228195 (2020), Abstract — Full Text
Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells: L.H. Hadi, et al.; PLoS One 10, e0143384 (2015), Application(s): Sphingolipid release in Cell Culture, Abstract — Full Text
S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells: K.P. Hopson, et al.; Am. J. Physiol. Cell Physiol. 300, C919 (2011), Abstract — Full Text
An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival: T. Blom, et al.; BMC Cell Biol. 11, 45 (2010), Abstract — Full Text
Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries: S. Salomone, et al.; Pharmacol. Res. 62, 465 (2010), Abstract — Full Text
Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.: D. Meyer zu Heringdorf, et al.; FEBS Lett. 554, 443 (2003), Abstract
Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.: F. Wang, et al.; Cancer Res. 59, 6185 (1999), Abstract
Synthesis and evaluation of a photolyzable derivative of sphingosine 1- phosphate–caged SPP: L. Qiao, et al.; Bioorg. Med. Chem. Lett. 8, 711 (1998), Abstract

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Sphingosine-1-phosphate, D-erythro

BML-SL140

S1P receptor agonist

34 citations

Alternative Name	(E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol, S1P
CAS	26993-30-6
Couple Type	Activator
Purity	≥98% (TLC)

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D-erythro-Sphingosine 1-phosphate (caged)

ALX-306-017

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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