D-AP5

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NMDA receptor antagonist

Active form of AP5. Potent NMDA receptor antagonist.

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Alternative Name	D(-)-2-Amino-5-phosphopentanoic acid
Appearance	White to off-white solid.
CAS	79055-68-8
Couple Target	NMDA receptor
Couple Type	Ligand
Formula	C₅H₁₂NO₅P
Identity	Determined by 1H-NMR.
MW	197.1
Purity	≥99% (HPLC)
Solubility	Soluble in water (acidify for better solubility).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro: S. Davis et al.; J. Neurosci. 12, 21 (1992), Abstract
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev. 10, 55 (1990), Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans et al.; Br. J. Pharmacol. 75, 65 (1982), Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord: J. Davies & C. Watkins; Brain Res. 235, 378 (1982), Abstract
Excitatory amino acid transmitters: J.C. Watkins et al.; Annu. Rev. Pharmacol. Toxicol. 21, 165 (1981), Abstract
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids: T.W. Stone et al.; Neuroscience 6, 2249 (1981), Abstract
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies et al.; Neurosci. Lett. 21, 77 (1981), Abstract

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