Cytochrome P450 1A2 (human) polyclonal antibody

Members of the cytochrome P-450 1A (CYP1A) sub-family are induced by a range of polycyclic aromatic compounds such as benzpyrene, 3-methylcholanthrene (Prod. No. BML-GR239), and pro-carcinogenic heterocyclic aromatic amines. Cigarette smoking has been reported to induce CYP1A2 in human liver, and appears to be a major catalyst in the hepatic activation of PhIP, (2-amino-1-methyl-6-phenylimidazo[4,5,b]-pyridine). The mono-oxygenase inhibitor inhibitor enoxacin induces CYP1A2 in rat liver, whereas a related compound ciprofloxacin does not.