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Cytochrome c monoclonal antibody (7H8.2C12)

ADI-AAM-175

1 citation

  • ADI-AAM-175-E   —   100 µg
    $397.00

Cytochrome c is an electron transport protein from mitochondria.  A primary means of caspase activation by p53 is through induction of cytochrome c release from mitochondria.  Cleavage of Bid, a Bcl 2 family member, by caspase-8 produces a truncated tBid molecule which triggers mitochondria release of cytochrome c which binds to the adaptor protein Apaf-1 and procaspase-9 to form a cytosolic apoptosome complex.  This event results in activation of procaspase-9 and its subsequent cleavage and activation of caspase-3 leading to the degradation of a series of cellular substrates and subsequently cell death.

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Regulatory Status

RUO – Research Use Only