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Cytochalasin B

BML-T108

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Ultra-pure; inhibits actin polymerization

Cytochalasin B is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It also inhibits monosaccharide transport across cell membranes. inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.

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Product Details

Appearance	White to off-white solid.
CAS	14930-96-2
Formula	C₂₉H₃₇NO₅
MW	479.6
Purity	≥98% (HPLC, TLC)
Solubility	Soluble in methanol or DMSO (20mg/ml).
Source	Isolated from Drechslera dematoidea

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CRM1 promotes capsid disassembly and nuclear envelope 2 translocation of adenovirus independently of its export function: F. Lagadec, et al.; J. Virol. , (2021), Abstract
Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation: A.M. George Thompson, et al.; Sci. Rep. 6, 24240 (2016), Application(s): Cell culture, Abstract
Glucose transporter and hypoxia-associated gene expression in the mammary gland of transition dairy cattle: Mattmiller, S. A., Corl, C. M., et al.; J. Dairy Sci. 94, 2912 (2011), Abstract
The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants: H.B. Pinkofsky et al.; Life. Sci. 66, 271 (2000), Abstract
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping: P.A. Theodoropoulos et al.; Biochem. Pharmacol. 47, 1875 (1994), Abstract
Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell. Biol. 105, 1473 (1987), Abstract
Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells: W.J. Malaisse; Cell. Biochem. Funct. 5, 183 (1987), Abstract
Effects of cytochalasin B on endocytosis and exocytosis: P. Davies & A.C. Allison; Front. Biol. 46, 143 (1978), Abstract
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out): J.W. Sanger & H. Holtzer; PNAS 69, 253 (1972), Abstract
Cytochalasin B: inhibition of glucose and glucosamine transport: R.D. Ebstensen & P.G. Plagemann; PNAS 69, 1430 (1972), Abstract

Last modified: May 29, 2024

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Cytochalasin B

BML-T108

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