Cystatin C is a major member of a large family of endogenous cysteine protease inhibitors found throughout the body. It inhibits proteases such as cathepsin B, H, DPPI, and papain, and is inactivated by neutrophil elastase. It is involved in cancer, rheumatoid arthritis, and other inflammatory diseases, and serves as a marker for renal function. Recently it was shown to bind and inhibit amyloid fibril formation, indicating therapeutic potential for Alzheimer’s disease.
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