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Cypermethrin

BML-PR100

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Calcineurin inhibitor

Synthetic type II pyrethroid. Potent calcineurin (protein phosphatase 2B) inhibitor IC₅₀~0.03 nM. May also have varied effects on ion channels. Serious doubts have been raised about the efficacy of this inhibitor.

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Product Details

Alternative Name	Alphamethrine, Pestanal, (R,S)-α-Cyano-3-phenoxybenzyl(1RS)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate
Appearance	White to off-white solid.
CAS	52315-07-8
Couple Target	Serine/threonine-protein phosphatase
Couple Type	Inhibitor
Formula	C₂₂H₁₉Cl₂NO₃
MI	14: 2767
MW	416.3
Purity	≥96% (HPLC) (mixture of isomers:racemic and cis/trans)
RTECS	GZ1250000
Solubility	Soluble in ethanol (25mg/ml). Insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Class II pyrethroids: noninhibitors calcineurin: A. Enz & E. Pombo-Villar; Biochem. Pharmacol. 54, 321 (1997), Abstract
Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation: J.H. Wang & A. Stelzer; Neuroreport 5, 2377 (1994), Abstract
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992), Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; Trends Pharmacol. Sci. 13, 236 (1992), Abstract

Last modified: May 29, 2024

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Cypermethrin

BML-PR100

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