Home Shop Cyclothiazide

Cyclothiazide

ALX-550-338

8 citations

Datasheet
Manual
SDS
CofA

Already have an account?

AMPA receptor activator

Potently inhibits the desensitization of AMPA receptors. Antihypertensive.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-3,4-dihydro-3[2-norbornen-5-yl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Appearance	White to off-white solid.
CAS	2259-96-3
Couple Target	AMPA receptor
Couple Type	Activator, Ligand
Formula	C₁₄H₁₆ClN₃O₄S₂
MI	14: 2754
MW	389.9
Purity	≥98% (HPLC (UV))
Solubility	Soluble in DMSO, methanol (36mg/ml) or dilute aqueous base (36mg/ml); insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity: Boggess, S. C., Gandhi, V., et al.; bioRxiv , (2024)
Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure: H. O’Leary, et al.; Neurobiol. Dis. 87, 134 (2015), Application(s): Blocked AMPAR desensitization, Abstract
Modulation of AMPA/kainate receptors by cyclothiazide increases cytoplasmic free Ca2+ and 45Ca2+ uptake in brain neurons: G. Cebers & S. Liljequist; Eur. J. Pharmacol. 290, 105 (1995), Abstract
Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists: M.A. Desai, et al.; J. Pharmacol. Exp. Ther. 272, 38 (1995), Abstract
Inhibition by cyclothiazide of neuronal nicotinic responses in bovine chromaffin cells: J.M. Nooney & A. Feltz; Br. J. Pharmacol. 114, 648 (1995), Abstract
Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes: R.L. Sharp, et al.; Eur. J. Pharmacol. 266, R1 (1994), Abstract
Desensitization of AMPA receptors upon multiquantal neurotransmitter release: L.O. Trussell, et al.; Neuron 10, 1185 (1993), Abstract
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors: L.A. Wong & M.L. Mayer; Mol. Pharmacol. 44, 504 (1993), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Cyclothiazide

ALX-550-338

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project