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Cyclophosphamide . monohydrate

ALX-400-051

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DNA alkylating agent

Alkylates DNA, forming DNA-DNA cross-links that result in inhibition of DNA synthesis and cell death. Interestingly the repair enzyme O⁶-alkylguanine-DNA alkyltransferase, long thought to be involved with resistance to methylating and chloroethylating agents, may also contribute to resistance to the cytotoxic and mutagenic effects of cyclophosphamide.

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Product Details

Alternative Name	2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide, Cytoxan
Appearance	White to off-white crystalline solid.
CAS	6055-19-2
Formula	C₇H₁₅CI₂N₂O₂P . H₂O
Identity	Determined by IR and UV.
MI	14: 2747
MW	261.1 . 18.0
Purity	≥97% (HPLC)
RTECS	RP6157750
Solubility	Soluble in water; slightly soluble in 100% ethanol.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Immunomodulatory Potential of the Industrialized Houttuynia cordata Fermentation Product In Vitro and in Wistar Rats: S. Utaiwat, et al.; Foods 10, 2582 (2021), Abstract
Protective effect of curcumin and chlorophyllin against DNA mutation induced by cyclophosphamide or benzo[a]pyrene: M.A. Ibrahim, et al.; Z. Naturforsch. 62, 215 (2007), Abstract
Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide: Z. Wang, et al.; Basic Clin. Pharmacol. Toxicol. 98, 411 (2006), Abstract
Mechanisms of resistance to the toxicity of cyclophosphamide: M.P. Gamcsik, et al.; Curr. Pharm. Des. 5, 587 (1999), Abstract
An overview of cyclophosphamide and ifosfamide pharmacology: R.A. Fleming; Pharmacotherapy 17, 146S (1997), Abstract
Induction of apoptosis in murine tumors by cyclophosphamide: R.E. Meyn, et al.; Cancer Chemother. Pharmacol. 33, 410 (1994), Abstract

Last modified: May 29, 2024

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Cyclophosphamide . monohydrate

ALX-400-051

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Handling & Storage

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