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Cyclopamine

BML-GR334

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Blocks Hedgehog signaling

Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells

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Product Details

Appearance	white to off-white powder
CAS	4449-51-8
Formula	C₂₇H₄₁NO₂
MW	411.6
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol (20mg/ml), DMSO (4mg/ml), dimethyl formamide (10mg/ml), methanol (7mg/ml). Insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Spinal dI4 Interneuron Differentiation From Human Pluripotent Stem Cells: Xu, J., Huang, L. J., et al.; Front. Mol. Neurosci. 15, 845875 (2022), Abstract
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway: A. Flury, et al.; Sci. Rep. 6, 23479 (2016), Application(s): Cell culture, Abstract — Full Text
Phosphodiesterase 4D inhibitors limit prostate cancer growth potential: Powers, G. L., Hammer, K. D., et al.; Mol. Cancer Res. 13, 149 (2015), Abstract
Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma: Y. Kim, et al.; Ann. Surg. Oncol. 21, 2684 (2014), Abstract
GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors: Leijten, J. C., Bos, S. D., et al.; Arthritis Res. Ther. 15, R126 (2013), Abstract
Internalization and induction of antioxidant messages by microvesicles contribute to the antiapoptotic effects on human endothelial cells: R. Soleti, et al.; Free Radic. Biol. Med. 53, 2159 (2012), Application(s): HUVEC cell culture, Abstract
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function: Allen, B. L., Song, J. Y., et al.; Dev. Cell 20, 775 (2011), Abstract
Gli2 expression and human bladder transitional carcinoma cell invasiveness: C.W. Mechlin, et al.; J. Urol. 184, 344 (2010), Abstract
Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA: F.K. Noubissi, et al.; Cancer Res. 69, 8572 (2009), Abstract — Full Text
Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity: S. Tabs & O. Avci; Eur. J. Dermatol. 14, 96 (2004), Abstract

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Cyclopamine

BML-GR334

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