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Cyclo [Arg-Gly-Asp-D-Phe-Val]

BML-AM100

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Integrin inhibitor

Integrin αvβ3 antagonist. Inhibits cell adhesion events mediated by αvβ3. Inhibits angiogenesis. Induces rapid regression of histologically distinct human tumors. Induces apoptosis of angiogenic blood vessels.

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Product Details

Appearance	Lyophilized solid.
CAS	137813-35-5
Formula	C₂₆H₃₈N₈O₇ . HOAc . 0.5H₂O
MW	643.7
Purity	≥98%
Sequence	Cyclo[Arg-Gly-Asp-D-Phe-Val]
Solubility	Soluble in DMSO (5 mg/ml) and PBS (1 mg/350μl).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

MAdCAM-1 Costimulates T Cells through Integrin α 4 β 7 to Cause Gene Expression Events Resembling Costimulation through CD28: H.A. DeBerg, et al.; Immunohorizons 6, 211 (2022), Abstract
Deiodinase-3 is a thyrostat to regulate podocyte homeostasis: Agarwal, S., Koh, K. H., et al.; EBioMedicine 72, 103617 (2021), Abstract
Testing the efficacy of Contrast Enhanced Ultrasound in detecting transplant rejection using a murine model of heart transplantation: K. Fischer, et al.; Am. J. Transplant. 17, 1791 (2017), Abstract
Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling: D.M. Cedano Prieto, et al.; PLoS One 12, e0184285 (2017), Application(s): Inhibition of beta3-CHO cell binding to IGF2, Abstract — Full Text
Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair: Christmann, M., Diesler, K., et al.; Oncotarget 8, 27754 (2017), Abstract
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels: P.C. Brooks, et al.; Cell 79, 1157 (1994), Abstract
Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1: M. Aumailley, et al.; FEBS Lett. 291, 50 (1991), Abstract

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Cyclo [Arg-Gly-Asp-D-Phe-Val]

BML-AM100

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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