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(+/-)Cyanopindolol hemifumarate

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Adrenergic receptor and serotonin receptor antagonist

ß-Adrenergic receptor antagonist. Serotonin 5HT1A/1B antagonist.

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Appearance	White solid.
CAS	69906-85-0
Couple Target	Adrenergic receptor, Serotonin receptor
Couple Type	Ligand
Formula	C₁₆H₂₁N₃O₂ . 1/2C₄H₄O₄
MW	345.4
Purity	≥99% (TLC)
Solubility	Soluble in warm water (2 mg/ml), DMSO (8 mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 4 months
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Comparison of the profiles of agonists as stimulants of the beta 3-adrenoceptor in vitro with their gastroprotective effects in the conscious rat: A. K. Bahl, et al.; Br. J. Pharmacol. 117, 580 (1996), Abstract — Full Text
Characterization of 5-hydroxytryptamine receptors in goat cerebral arteries: F. J. Miranda, et al.; Gen. Pharmacol. 26, 1267 (1995), Abstract
Blockade of the central 5-HT autoreceptor by beta-adrenoceptor antagonists: D. N. Middlemiss, et al.; Eur. J. Pharmacol. 120, 51 (1986), Abstract
Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex: E. Schlicker, et al.; Naunyn. Schmied. Arch. Pharmacol. 331, 398 (1985), Abstract
Specificity of the beta 2-adrenergic receptor stimulating cyclic AMP accumulation in the intermediate lobe of rat pituitary gland: H. Meunier & F. Labrie; Eur. J. Pharmacol. 81, 411 (1982), Abstract

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