CVT-313

ALX-270-393

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CDK/cyclin inhibitor

Specific inhibitor of CDK2/cyclin A (IC₅₀=500nM) and CDK2/cyclin E (IC₅₀=500nM). Also inhibits CDK1/cyclin B (IC₅₀=4.2µM) and CDK4/cyclin D1 (IC₅₀=215µM).

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Product Details

Alternative Name	6-(4-Methoxybenzylamino)-2-[bis(2-hydroxyethylamino)]-9-isopropylpurine
Appearance	White crystalline solid.
CAS	199986-75-9
Couple Target	CDK, Cyclin
Couple Type	Inhibitor
Formula	C₂₀H₂₈N₆O₃
MW	400.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, dimethyl formamide or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The structure and substrate specificity of human Cdk12/Cyclin K: Bösken, C. A., Farnung, L., et al.; Nat. Commun. 5, 3505 (2014), Abstract
Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling: R.N. Bhattacharjee, et al.; Mol. Cell. Biol. 21, 5417 (2001), Abstract — Full Text
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation: E.E. Brooks, et al.; J. Biol. Chem. 272, 29207 (1997), Abstract — Full Text

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CVT-313

ALX-270-393

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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