SOD (Superoxide dismutase) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells, they are: EC SOD (extracellular SOD), Cu/Zn SOD (copper and zinc-containing SOD) and Mn SOD (manganese-containing SOD).
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Product Details
Alternative Name |
Superoxide Dismutase (Cu-Zn), Superoxide dismutase 1, SOD1 |
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Application |
WB |
Application Notes |
Detects a band of ~23kDa (human) or ~19kDa (other species) by Western blot. |
Formulation |
Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
Gene/Protein Identifier |
NP_058746 (RefSeq) |
Host |
Rabbit |
Immunogen |
Native rat Cu/Zn SOD. |
Purity Detail |
Protein A affinity purified. |
Recommendation Dilutions/Conditions |
Western Blot (0.5µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
Source |
Purified from rabbit serum. |
Species Reactivity |
Human, Mouse, Rat |
UniProt ID |
P07632 |
Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
Handling |
Avoid freeze/thaw cycles. |
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Long Term Storage |
-20°C |
Shipping |
Blue Ice |
Regulatory Status |
RUO – Research Use Only |
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- Repurposed Nrf2 activator dimethyl fumarate rescues muscle inflammation and fibrosis in an aggravated mdx mouse model of Duchenne muscular dystrophy: Kourakis, S., Timpani, C. A., et al.; Redox Biol. 84, 103676 (2025), Abstract
- Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.: Pelaez, M. C., Fiore, F., et al.; Neurotherapeutics 21, e00388 (2024), Application(s): WB / Reactant(s): Mouse, Abstract
- Pan-neuronal expression of human mutant SOD1 in Drosophila impairs survival and motor performance, induces early neuroinflammation and chromosome aberrations.: Liguori, F., Alberti, F., et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1870, 167192 (2024), Reactant(s): Drosophila melanogaster, Abstract
- Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice: Xu, H., Czyżowska, A., et al.; J. Physiol. 601, 5277 (2023), Abstract
- Dimethyl fumarate modulates the dystrophic disease program following short-term treatment: Timpani, C. A., Kourakis, S., et al.; JCI Insight 8, (2023), Abstract
- Regulation by Nrf2 of IL-1β-induced inflammatory and oxidative response in VSMC and its relationship with TLR4.: González-Carnicero, Z., Hernanz, R., et al.; Front. Pharmacol. 14, 1058488 (2023), Reactant(s): Mouse, Abstract
- Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis: S. Bhaskaran, et al.; Redox Biol. 59, 102550 (2023), Abstract
- Resistance to Obesity in SOD1 Deficient Mice with a High-Fat/High-Sucrose Diet.: Sato, A., Shiraishi, Y., et al.; Antioxidants (Basel) 11, (2022), Application(s): WB / Reactant(s): Mouse, Abstract
- Dimethyl fumarate modulates the Duchenne muscular dystrophy disease program following short-term treatment in mdx mice: Timpani, C. A., Kourakis, S., et al.; bioRxiv , (2022)
- Altered Mitochondrial Opa1-Related Fusion in Mouse Promotes Endothelial Cell Dysfunction and Atherosclerosis: Chehaitly, A., Guihot, A. L., et al.; Antioxidants (Basel) 11, (2022), Abstract
- Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation.: Xu, H., Ahn, B., et al.; Sci. Adv. 8, eadd7377 (2022), Application(s): WB / Reactant(s): Mouse, Abstract
- Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord: B.G. Trist, et al.; Brain 145, 3108 (2022), Abstract
- PPARγ as an indicator of vascular function in an experimental model of metabolic syndrome in rabbits: S. Guerra-Ojeda, et al.; Atherosclerosis 332, 16 (2021), Application(s): WB, Abstract
- Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia.: Xu, H., Ranjit, R., et al.; J. Cachexia Sarcopenia Muscle 12, 1582 (2021), Application(s): WB / Reactant(s): Mouse, Abstract
- Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching: Deprez, A., Orfi, Z., et al.; Clin. Sci. (Lond.) 135, 2589 (2021), Abstract
- Nitric oxide and oxidative stress pathways do not contribute to sex differences in renal injury and function in Dahl SS/Jr rats: H.R. Turbeville, et al.; Physiol. Rep. 13, e14440 (2020), Abstract — Full Text
- Sodium nitrate co-supplementation does not exacerbate low dose metronomic doxorubicin-induced cachexia in healthy mice.: Campelj, D. G., Debruin, D. A., et al.; Sci. Rep. 10, 15044 (2020), Application(s): WB / Reactant(s): Mouse, Abstract
- The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction.: Campelj, D. G., Timpani, C. A., et al.; Cancers (Basel) 12, (2020), Application(s): WB, Abstract
- TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation: Semmler, S., Gagné, M., et al.; J. Biol. Chem. 295, 3808 (2020), Abstract
- NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction: Priestley, J. R. C., Fink, K. E., et al.; Microcirculation 26, e12575 (2019), Abstract
- TNF receptor associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation: Semmler, S., Gagné, M., et al.; bioRxiv , (2019)
- Diallyl Trisulfide Protects Rat Brain Tissue against the Damage Induced by Ischemia-Reperfusion through the Nrf2 Pathway.: Silva-Islas, C. A., Chánez-Cárdenas, M. E., et al.; Antioxidants (Basel) 8, (2019), Reactant(s): Rat, Abstract
- Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation.: Quadrilatero, J., Bloemberg, D., et al.; Autophagy 15, 1606 (2019), Application(s): WB, Abstract
- Chronic exercise impairs nitric oxide pathway in rabbit carotid and femoral arteries: P. Marchio, et al.; J. Physiol. 596, 4361 (2018), Abstract
- Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects.: Knowels, G., Marcinek, D. J., et al.; PLoS One 12, e0181086 (2017), Application(s): WB / Reactant(s): Mouse, Abstract
- Augmented Contractility to Noradrenaline in Femoral Arteries from the Otsuka Long-Evans Tokushima Fatty Rat, a Model of Type 2 Diabetes.: Kobayashi, S., Matsumoto, T., et al.; Biol. Pharm. Bull. 40, 2061 (2017), Application(s): WB / Reactant(s): Rat, Abstract
- SOD1 dimerization monitoring using a novel split NanoLuc, NanoBit: Oh-hashi, K., Hirata, Y., et al.; Cell Biochem. Funct. 34, 497 (2016), Abstract
- Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats: T. Shibaguchi, et al.; Physiol. Rep. 4, e12885 (2016), Application(s): SDS-PAGE and western blotting, Abstract — Full Text
- Scheme of Ischaemia-triggered Agents during Brain Infarct Evolution in a Rat Model of Permanent Focal Ischaemia: P. Bonova, et al.; J. Mol. Neurosci. 57, 73 (2015), Application(s): Western Blot, Abstract
- S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2: E. Garcia, et al.; Free Radic. Res. 48, 159 (2014), Application(s): Western Blot of stratial & nigral mouse tissue lysates, Abstract
- The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice: Gano, L. B., Donato, A. J., et al.; Am. J. Physiol. Heart Circ. Physiol. 307, H1754 (2014), Abstract
- Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats: Raffai, G., Durand, M. J., et al.; Am. J. Physiol. Heart Circ. Physiol. 301, H1341 (2011), Abstract
- A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice: D. Jaarsma, et al.; Hum. Mol. Genet. 17, 2849 (2008), Application(s): WB using mouse tissue, Abstract
- Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis: H.D. Durham, et al.; J. Biol. Chem. 276, 12791 (2001), Application(s): WB using human samples, Abstract
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