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The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA-4 also functions as an immune checkpoint protein, and anti- CTLA-4 antibodies have been successfully used in the treatment of cancer. Mutations in the CTLA-4 gene have been implicated in multiple autoimmune diseases.
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Western blot analysis of CTLA-4 in overexpressing HEK293 cells. CTLA-4 antibody at 0.125 and 0.25 µg/mL.
Immunohistochemistry of CTLA-4 in human lymph node tissue with CTLA-4 antibody at 5 µg/mL.
Immunofluorescence of CTLA-4 in transfected HEK293 cells with CTLA-4 antibody at 20 µg/mL. Red: CTLA4 Antibody [1E6] (RF16011) Blue: DAPI staining
Immunocytochemistry of CTLA-4 in transfected HEK293 cells with CTLA-4 antibody at 5 ug/mL. Lower left: Immunocytochemistry in transfected HEK293 cells with control mouse IgG antibody at 5 ug/mL.
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