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Copper(II) Protoporphyrin IX (free acid)

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Negative control for the heme oxygenase inhibitor zinc protoporphyrin IX (Prod. No. ALX-430-049).

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Appearance	Red to brown solid.
Formula	C₃₄H₃₂CuN₄O₄
MW	624.2
Purity	≥95%
Solubility	Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma: P.V. Raninga, et al.; Redox Biol. 8, 175 (2016), Application(s): HO-1 inhibition, Abstract
Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii: S.R. Glaum & R.J. Miller; Mol. Pharmacol. 43, 965 (1993), Abstract
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin: R.J. Chernick, et al.; Hepatology 10, 365 (1989), Abstract

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