Convulxin

ALX-350-100

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Manual
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Heterodimeric C-type lectin

Heterodimeric C-type lectin. Activates mammalian platelets via binding and clustering of p62/GPVI-receptors under physiological conditions.

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Product Details

Activity	<50ng/ml (minimal concentration to induce maximum activation of washed human platelets).
Application Notes	Can be used for studies on platelet receptors.
CAS	37206-04-5
Formulation	Lyophilized.
MW	~84kDa.
Purity	≥90% (SDS-PAGE)
Purity Detail	Partially purified by multi-step chromatography.
Reconstitution	Reconstitute in 10mM HEPES buffer, pH 7.2. (We recommend adding a carrier protein such as BSA to the reconstitution buffer and any subsequent dilution buffers to prevent absorption on plastic surfaces.)
Solubility	Soluble in organic buffer (HEPES).
Source	Isolated from Crotalus durissus terrificus snake venom.
UniProt ID	O93426

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C.
Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca2+ entry in platelets: Reusswig, F., Yilmaz, M., et al.; Front. Cardiovasc. Med. 10, 1171831 (2023), Abstract
Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets: Larsen, H. J., Byrne, D., et al.; Arterioscler. Thromb. Vasc. Biol. 43, 1990 (2023), Abstract
Deletion of 12-lipoxygenase normalizes platelet function after storage and transfusion in thrombocytopenic mice: Larsen, H. J., Byrne, D., et al.; bioRxiv , (2022)
Ablation of Collagen VI leads to the release of platelets with altered function: V. Abbonante, et al.; Blood Adv. 5, 5150 (2021), Abstract
The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis: Moujalled, D., Gangatirkar, P., et al.; Cell Death Dis. 12, 133 (2021), Abstract
Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway: Zhao, B., Li, G. P., et al.; Exp. Ther. Med. 21, 220 (2021), Abstract
Combined Antiplatelet Therapy Reduces the Proinflammatory Properties of Activated Platelets: A.C.A. Heinzmann, et al.; TH Open 5, e533 (2021), Abstract
Activated Endothelial TGFβ1 Signaling Promotes Venous Thrombus Nonresolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension: Bochenek, M. L., Leidinger, C., et al.; Circ. Res. 126, 162 (2020), Abstract
Feedback Regulation of Syk by Protein Kinase C in Human Platelets: S. Makhoul, et al.; Int. J. Mol. Sci. 21, 176 (2019), Abstract
Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation: K. Kiouptsi, et al.; Sci. Rep. 7, 7621 (2017), Abstract — Full Text

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Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Specific Protocol

Assay performed in aggregometer:

Incubate 485µl platelets suspension (5x10⁸ platelets/ml) for 1-2 minutes at 37°C until base line is stable.
Add 5µl 200mM CaCl₂.
Add 5µl 200mM MgCl₂.
Wait until baseline is stable.
Add 5µl collagen solution (0.5mg/ml) for positive control OR add 5µl convulxin (0.1µg/ml in HEPES).
Measure aggregation at 37°C.

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