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Conduritol B Epoxide

BML-S104

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Glycosidase inhibitor

A potent, irreversible inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Has been employed in in vitro and animal models for Gaucher’s disease. It raises intracellular levels of glucosylceramide by inhibiting glucosylceramidase.

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Product Details

Alternative Name	D,L-1,2-Anhydro-myo-inositol
Appearance	White solid.
CAS	6090-95-5
Couple Target	Glucosidase, Glycosidase
Couple Type	Inhibitor
Formula	C₆H₁₀O₅
Identity	Determined by 1H-NMR and MS.
MW	162.1
Purity	≥96% (TLC)
Solubility	Soluble in water (25mg/ml) or in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Product must be stored under argon.
Handling	Hygroscopic. Protect from moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease: Y. Oji, et al.; Brain 143, 1190 (2020), Application(s): Treatment of iPSC-derived dopaminergic neurons, Abstract
In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling: C.L. Kuo, et al.; FEBS J. 286, 584 (2019), Application(s): Treatment of HEK293T cells, Abstract
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases: A.R. Margues, et al.; J. Lipid Res. 57, 451 (2016), Application(s): Inhibition of GBA, Abstract — Full Text
Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases: M.J. Ferraz, et al.; FEBS Lett. 590, 716 (2016), Application(s): Treatment of HEK293T cells, Abstract
Normalization of liver glucosylceramide levels in the Gaucher” mouse by phosphatidylserine injection”””: S.C. Datta & N.S. Radin; Biochem. Biophys. Res. Commun. 152, 155 (1988), Abstract
beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell: D.S. Newburg, et al.; Biochim. Biophys. Acta 877, 121 (1986), Abstract
Destruction and resynthesis of mouse beta-glucosidases: A. Hara & N.S. Radin; Biochim. Biophys. Acta 582, 412 (1979), Abstract
The Gaucher mouse: differential action of conduritol B epoxide and reversibility of its effects: M.C. Stephens, et al.; J. Neurochem. 30, 1023 (1978), Abstract
Mechanism of action of glycoside-splitting enzymes. V. Labelling of the active center of beta-glucosidases A and B from sweet almond emulsin with (3H)6-bromo-6-deoxyconduritol B epoxide: G. Legler; Hoppe-Seyler’s Z. Physiol. Chem. 351, 25 (1970), Abstract

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Conduritol B Epoxide

BML-S104

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