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Concanamycin A

ALX-380-034

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ALX-380-034-M001 — 1 mg

$3,528.00

Concanamycin A quantity
ALX-380-034-C025 — 25 µg

$334.00

Concanamycin A quantity
ALX-380-034-C100 — 100 µg

$1,004.00

Concanamycin A quantity

H⁺ ATPase inhibitor

Antibiotic. More potent and specific H⁺-ATPase inhibitor than bafilomycin A₁(Prod. No. BML-CM110). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production. Inhibits Autophagy.

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Product Details

Alternative Name	Folimycin
Appearance	White to off-white solid (sub-milligram quantities will appear as clear film).
CAS	80890-47-7
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₄₆H₇₅NO₁₄
MW	866.1
Purity	≥95% (HPLC)
RTECS	CB9732000
Solubility	Soluble in methanol, DMSO or acetonitrile; insoluble in water.
Source	Isolated from Streptomyces sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light . Solutions are more stable when stored at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels: Zeng, Q., Antia, A., et al.; Mbio 15, e0228723 (2024), Abstract
Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target: Zeng, Q., Antia, A., et al.; bioRxiv , (2022)
STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production: Li, D., Wu, R., et al.; Cell Rep. 29, 1249 (2019), Abstract
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma: V.K. Emruli, et al.; BMC Cancer 16, 493 (2016), Application(s): Transient knock-down of V-ATPase, Abstract — Full Text
Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells: V. Teixeira, et al.; Biochim. Biophys. Acta 1861, 21 (2016), Application(s): Cell Culture, Abstract
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex: S. Ding, et al.; PLoS Pathology 12, e1005929 (2016), Application(s): Cell treatment, Abstract — Full Text
Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions: R. Dawaliby, et al.; Mol. Biol. Cell 21, 4173 (2010), Abstract — Full Text
Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk–a pivotal role of HMGB1: M.T. Melki, et al.; PLoS Pathog. 6, e1000862 (2010), Abstract — Full Text
Degradation of oxidized proteins by autophagy during oxidative stress in Arabidopsis: Y. Xiong, et al.; Plant Physiol. 143, 291 (2007), Abstract
Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells: J. Hong, et al.; J. Pharmacol. Exp. Ther. 319, 672 (2006), Abstract

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Alternative Name	NSC 381866
CAS	88899-55-2
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ALX-380-034

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Concanamycin A

ALX-380-034

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Bafilomycin A1

BML-CM110

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Bafilomycin A₁