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Compound A

ALX-550-516

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Glucocorticoid receptor modulator

Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. BML-EI126) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.

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Product Details

Alternative Name	CpdA, 2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
Appearance	White to off-white solid.
CAS	14593-25-0
Formula	C₁₁H₁₄ClNO₂ . HCl
MW	227.7 . 36.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, 100% ethanol or water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
Handling	Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.
Short Term Storage	+4°C
Long Term Storage	-80°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Relative contribution of molecular mechanisms to cumulative ligand-mediated downregulation of GRα: L.L. Spies, et al.; Biochem. Biophys. Res. Commun. 602, 113 (2022), Abstract
Glucocorticoids decrease the production of glucagon-like peptide-1 at the transcriptional level in intestinal l-cells: T. Sato, et al.; Mol. Cell Endocrinol. 406, 60 (2015), Application(s): Cell Culture, Assay, Abstract
Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis: G. van LOO, et al.; Mol. Endocrinol. 24, 310 (2010), Abstract
A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance: V. Gossye, et al.; Ann. Rheum. Dis. 69, 291 (2010), Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol. 180, 2608 (2008), Abstract
A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS 102, 15827 (2005), Abstract

Related Products

Dexamethasone

BML-EI126

Glucocorticoid receptor ligand

36 citations

Alternative Name	9α-Fluoro-16α-methylprednisolone
CAS	50-02-2
Couple Type	Activator, Ligand
Purity	≥98% (HPLC)

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Compound A

ALX-550-516

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