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Compound 56

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EGFR inhibitor

Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC₅₀=6pM).

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Alternative Name	4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
Appearance	White to off-white powder.
CAS	171745-13-4
Couple Target	EGFR
Couple Type	Inhibitor
Formula	C₁₈H₁₈BrN₃O₂
MW	388.3
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO (200mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor: A.J. Bridges, et al.; J. Med. Chem. 39, 267 (1996), Abstract

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