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Compound 15e

ALX-270-455

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PI3 kinase inhibitor

Potent and specific inhibitor of phosphoinositide 3-kinasep110α isoform (IC₅₀=0.0020µM). p110β isoform (IC₅₀=0.016µM)p110γ isoform (IC₅₀=0.66µM)C2β isoform (IC₅₀=0.22µM). Inhibits proliferation of A375 melanoma cells (IC₅₀=0.58µM). Inhibits proliferation of U87MG human glioblastoma cells (IC₅₀=1.10.µM).Inhibits proliferation of A2780 human ovarian cells (IC₅₀=0.27µM).

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Product Details

Alternative Name	3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
Appearance	White to off-white solid.
CAS	371943-05-4
Couple Target	PI3 kinase
Couple Type	Inhibitor
Formula	C₁₆H₁₅N₃O₂S
MW	313.4
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO or dioxane.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation: Pritchard, R. A., Falk, L., et al.; Pain 157, 137 (2016), Abstract
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer: A.J. Folkes; J. Med. Chem. 51, 5522 (2008), Abstract
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors: M. Hayakawa, et al.; Bioorg. Med. Chem. 14, 6847 (2006), Abstract

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Compound 15e

ALX-270-455

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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