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Colistin . sulfate

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Antibiotic

Polymyxin antibiotic. Binds to lipids on the cell cytoplasmic membrane. Disrupts cell wall integrity. Effective against Gram-negative bacteria.

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Activity	Potency is >19’900 u/mg (on dry basis).
Alternative Name	Polymyxin E . sulfate
Appearance	White to off-white powder.
CAS	1264-72-8
MI	14: 2479
Purity Detail	Mixture of >30 compounds, primarily colistin A and B.
RTECS	TR1500000
Solubility	Soluble in water (50mg/ml).
Source	Isolated from Bacillus colistinus.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Polymyxins: wisdom does not always come with age: Z. Kassamali, et al.; Clin. Infect. Dis. 57, 877 (2013), Abstract
The clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med. 7, 434 (2001), (Review), Abstract
Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother. 33, 960 (1999), (Review), Abstract
Antibacterial action of colistin (polymyxin E) against Mycobacterium aurum: H.L. David & N. Rastogi; Antimicrob. Agents Chemother. 27, 701 (1985), Abstract — Full Text

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