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Inhibitor of tubulin polymerization
Depolymerizes microtubules and inhibits tubulin polymerization. Induces apoptosis in a variety of cells.
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Product Details
| Appearance |
White to off-white solid. |
|---|---|
| CAS |
64-86-8 |
| Formula |
C22H25NO6 |
| MI |
14: 2471 |
| MW |
399.4 |
| Purity |
≥94% (HPLC) |
| RTECS |
GH0700000 |
| Solubility |
Soluble in DMSO (14mg/ml), 100% ethanol (7mg/ml), water (7mg/ml) or dimethylformamide (12mg/ml). |
| Source |
Isolated from Colchicum autumnale. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light and moisture. |
| Long Term Storage |
+4°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Magnetic colloidal nanoformulations to remotely trigger mechanotransduction for osteogenic differentiation: M. Estévez, et al.; J. Colloid Interface Sci. 15, 664 (2024), Abstract
- Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs: A.R. Choi, et al.; Anticancer Res. 36, 5859 (2016), Application(s): Cell treatment with KBV20C cells, Abstract — Full Text
- Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury: T. Grevesse, et al.; Sci. Rep. 5, 9475 (2015), Application(s): Cell Culture, Abstract — Full Text
- Interaction of Mycobacterium leprae with human airway epithelial cells: adherence, entry, survival, and identification of potential adhesins by surface proteome analysis: Silva, C. A., Danelishvili, L., et al.; Infect. Immun. 81, 2645 (2013), Abstract
- Spatial coordination between cell and nuclear shape within micropatterned endothelial cells: Versaevel, M., Grevesse, T., et al.; Nat. Commun. 3, 671 (2012), Abstract
- Update on colchicine and its mechanism of action: Y. Molad; Curr. Rheumatol. Rep. 4, 252 (2002), Abstract
- Colchicine protects mice from the lethal effect of an agonistic anti- Fas antibody: G. Feng & N. Kaplowitz; J. Clin. Invest. 105, 329 (2000), Abstract
- Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress: Y.L. Hu, et al.; Am. J. Physiol. 277, H1593 (1999), Abstract
- Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells: A.M. Gorman, et al.; Eur. J. Neurosci. 11, 1067 (1999), Abstract
- General features of the recognition by tubulin of colchicine and related compounds: Y. Engelborghs; Eur. Biophys. J. 27, 437 (1998), Abstract
- Antimitotic natural products and their interactions with tubulin: E. Hamel et al.; Med. Res. Rev. 16, 207 (1996), Abstract
- Colchicine induces apoptosis in cerebellar granule cells: E. Bonfoco, et al.; Exp. Cell. Res. 218, 189 (1995), Abstract
- Inhibition of drug-induced apoptosis by survival factors in PC12 cells: L. Lindenboim, et al.; J. Neurochem. 64, 1054 (1995), Abstract
- Disruption of microtubules inhibits the stimulation of tissue plasminogen activator expression and promotes plasminogen activator inhibitor type 1 expression in human endothelial cells: L. Santell, et al.; Exp. Cell. Res. 201, 358 (1992), Abstract
- The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells: M.F. Lueng & A.C. Sartorelli; Leuk. Res. 16, 929 (1992), Abstract
- Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine: E.D. Salmon, et al.; J. Cell. Biol. 99, 1066 (1984), Abstract
- Proposed mechanism for colchicine poisoning of microtubules reassembled in vitro from Strongylocentrotus purpuratus sperm tail outer doublet tubulin: K.W. Farrell & L. Wilson; Biochemistry 19, 3048 (1980), Abstract
- Kinetics and mechanism of colchicine binding to tubulin: evidence for ligand-induced conformational change: D.L. Garland; Biochemistry 17, 4266 (1978), Abstract
- Fluorometric assay of tubulin-colchicine complex: T. Arai & T. Okuyama; Anal. Biochem. 69, 443 (1975), Abstract
- A new colchicine binding assay for tubulin: P. Sherline, et al.; Anal. Biochem. 62, 400 (1974), Abstract
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