Home Shop Cobalt (III) Protoporphyrin IX chloride

Cobalt (III) Protoporphyrin IX chloride

ALX-430-076

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Heme oxygenase activator

The ability of cobalt ions to induce heme oxygenase (HO) activity in liver cells was first reported almost 30 years ago. Cobalt protoporphyrin IX (CoPP) was later shown to be a substrate for HO, now identified as the inducible isoform HO-1 (heast shock protein 32; hsp32). CoPP has been shown to down-regulate various cytochrome P450 isoforms and various mechanisms of action have been attributed to CoPP and other metalloporphyrins.

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Product Details

Appearance	Dark purple solid.
CAS	102601-60-5
Couple Target	Heme oxygenase
Couple Type	Activator
Formula	C₃₄H₃₂CoN₄O₄ . Cl
Identity	Identity determined by UV/VIS and NMR.
MW	654.5
Purity	≥95% (TLC)
Solubility	Soluble in basic aqueous solutions at pH between 8.5-9.0. Once in solution pH can be adjusted to physiological pH.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cobalt Protoporphyrin Downregulates Hyperglycemia-Induced Inflammation and Enhances Mitochondrial Respiration in Retinal Pigment Epithelial Cells: Fang, P. H., Lin, T. Y., et al.; Antioxidants (Basel) 14, 92 (2025), Abstract
Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness: Leineweber, W. D., Rowell, M. Z., et al.; iScience 27, 110661 (2024), Abstract
Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions: Fang, P. H., Lai, Y. Y., et al.; Mol. Med. 28, 71 (2022), Abstract
Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes: A. Nithichanon, et al.; Sci. Rep. 10, 10297 (2020), Abstract — Full Text
Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR: N.G. Abraham et al.; Cell Mol Biol (Noisy-le-grand) 48, 895 (2002), Abstract
Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury: F. Amersi et al.; J. Clin. Invest. 104, 1631 (1999), Abstract
Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response: E.E. Cable et al.; Mol. Cell. Biochem. 169, 13 (1997), Abstract
Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the heme protein: D.W. Rosenberg et al.; Pharmacology 51, 254 (1995), Abstract
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver: M.D. Maines et al.; PNAS 73, 1499 (1976), Abstract
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity: M.D. Maines & A. Kappas; PNAS 71, 4293 (1974), Abstract

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Cobalt (III) Protoporphyrin IX chloride

ALX-430-076

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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