CNQX

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AMPA/kainate receptor antagonist

Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. For the more soluble form see CNQX . disodium salt (Prod. No. ALX-550-283).

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Alternative Name	6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
Appearance	Off-white to yellow powder.
CAS	115066-14-3
Couple Target	AMPA receptor, Kainate receptor
Couple Type	Inhibitor, Ligand
Formula	C₉H₄N₄O₄
MW	232.2
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml) or dilute aqueous base.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for several months when stored at -20°C.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selective glycinergic input from vGluT3 amacrine cells confers a suppressed-by-contrast trigger feature in a subtype of M1 ipRGCs in the mouse retina: Lee, S., Chen, M., et al.; J. Physiol. 599, 5047 (2021), Abstract
Brainstem metabotropic glutamate receptors reduce food intake and activate dorsal pontine and medullar structures after peripheral bacterial lipopolysaccharide administration: L. Chaskiel, et al.; Neuropharmacology 107, 146 (2016), Application(s): Cell culture, Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano- 7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4- yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990), Abstract
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science, 241, 701 (1988), Abstract

Related Products

AMPA/kainate receptor antagonist

Alternative Name	6-Cyano-7-nitroquinoxaline-2,3-dione . 2Na
CAS	115066-14-3 (non-salt)
Couple Type	Inhibitor, Ligand
Purity	≥98% (TLC)

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