Clusterin (secretory form) (human), (recombinant) (His-tag)

Clusterin is a secretory heterodimeric disulfied-linked glycoprotein containing 449 amino acids that is expressed in virtually all tissues, and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. In addition, clusterin is up/ down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.