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Clofilium . tosylate

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K⁺ channel blocker

K⁺ channel blocker. Antiarrhytmic. Cardiac depressant.

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Alternative Name	4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium . tosylate
Appearance	White solid.
CAS	92953-10-1
Couple Target	Potassium channel
Couple Type	Blocker
Formula	C₂₁H₃₇ClN . C₇H₇O₃S
Identity	Determined by 1H-NMR.
MW	339.0 . 171.2
Purity	≥95% (HPLC)
Solubility	Soluble in water, methanol or DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis: N. Adragna, et al.; Front. Cell. Neurosci. 9, 255 (2015), Application(s): Cell culture , Abstract
The differential response of normal and ischaemic Purkinje fibres to clofilium, d-sotalol and bretylium: W.B. Gough & N. el-Sherif; Cardiovasc. Res. 23, 554 (1989), Abstract
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked: J.P. Arena & R.S. Kass; Mol. Pharmacol. 34, 60 (1988), Abstract

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