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Clofibrate

ALX-270-256

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PPARα activator

Activates PPARα. Induces cytochrome P450 4A1 and 4A3 which catalize the omega-oxidation of fatty acids and prostaglandins.

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Product Details

Alternative Name	2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
Appearance	Colorless oil.
CAS	637-07-0
Couple Target	PPAR
Couple Type	Activator, Ligand
Formula	C₁₂H₁₅ClO₃
MI	14: 2377
MW	242.7
Purity	≥98% (GC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions are stable for up to 6 months when stored at –20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor: M. Göttlicher, et al.; PNAS 89, 4653 (1992), Abstract
Effect of clofibrate treatment on hepatic prostaglandin catabolism and action: E.P. Brass & L.J. Ruff; J. Pharmacol. Exp. Ther. 257, 1034 (1991), Abstract
Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha: T. Aoyama et al.; J. Lipid. Res. 31, 1477 (1990), Abstract

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Clofibrate

ALX-270-256

Product Details

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