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The cytoskeleton-linking membrane protein of 62kDa (CLIMP-63) is a marker for the reticular subdomain of the rough endoplasmatic reticulum (ER) and is excluded from the outer nuclear membrane. Concentration of CLIMP-63 into patches may enhance microtubule binding on the cytosolic side and contribute to ER morphology by the formation of a protein scaffold in the lumen of the ER, linking the rough ER to microtubules.
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This antibody is covered by our Worry-Free Guarantee.
Product Details
| Alternative Name |
ER protein p63, Cytoskeleton-linking membrane protein of 63kDa |
|---|---|
| Application |
ELISA, Flow Cytometry, ICC, IHC (FS), IP, WB |
| Clone |
G1/296 |
| Formulation |
Liquid. In PBS containing 0.1% sodium azide. |
| Host |
Mouse |
| Immunogen |
Human CLIMP-63 (cytoskeleton-linking membrane protein of 63kDa) from Caco-2 cells golgi membrane fraction. |
| Isotype |
IgG2aκ |
| Purity Detail |
Protein G-affinity purified. |
| Source |
Purified from hybridoma tissue culture supernatant. |
| Species Reactivity |
Human, Monkey |
| UniProt ID |
Q07065 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. |
|---|---|
| Short Term Storage |
+4°C |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Cytoskeleton-associated protein 4 (CKAP4) affects podocyte cytoskeleton dynamics in diabetic kidney disease: Boi, R., Lassén, E., et al.; JCI Insight , e181298 (2025), Abstract
- Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase: Avci, D., Heidasch, R., et al.; J. Biol. Chem. 300, 105644 (2024), Abstract
- Endoplasmic reticulum-plasma membrane contact gradients direct cell migration.: Gong, B., Johnston, J. D., et al.; Nature 631, 415 (2024), Reactant(s): Human, Abstract
- Dynamics of CLIMP-63 S-acylation control ER morphology: P.A. Sandoz, et al.; Nat. Commun. 14, 264 (2023), Abstract
- The endoplasmic reticulum adopts two distinct tubule forms: Wang, B., Zhao, Z., et al.; PNAS 119, e2117559119 (2022), Abstract
- Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation: J. Bock, et al.; Cell Rep. 40, 111175 (2022), Abstract
- Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH.: Moran, T. M., Kraus, T. A., et al.; Commun. Biol. 5, 387 (2022), Application(s): ICC-IF / Reactant(s): Human, Abstract
- The endoplasmic reticulum adopts two distinct forms of tubules: Wang, B., Zhao, Z., et al.; Research Square , (2021)
- Intramembrane protease SPP defines a cholesterol-regulated switch of the mevalonate pathway: Heidasch, R., Avci, D., et al.; bioRxiv , (2021)
- FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins.: Wu, Y., Li, D., et al.; J. Cell Biol. 220, (2021), Application(s): ICC-IF, Abstract
- SEC24A facilitates colocalization and Ca2+ flux between the endoplasmic reticulum and mitochondria.: Higgs, H. N., Supattapone, S., et al.; J. Cell Sci. 134, (2021), Application(s): WB, Abstract
- Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis: G. Yedida, et al.; Cell Death Dis. 10, 521 (2019), Abstract
- The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins: Avci, D., Malchus, N. S., et al.; J. Biol. Chem. 294, 2786 (2019), Abstract
- Recombinant Hepatitis E Viruses Harboring Tags in the ORF1 Protein: Szkolnicka, D., Pollán, A., et al.; J. Virol. 93, (2019), Abstract
- Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion: J. Gouttenoire, et al.; PLoS Pathog. 14, e1007471 (2018), Abstract
- Determinants for Membrane Association of the Hepatitis C Virus NS2 Protease Domain: C.M. Lange, et al.; J. Virol. 88, 6519 (2014), Abstract
- Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation: J. Chang, et al.; PNAS 110, 14954 (2013), Application(s): ICC using human cells, Abstract — Full Text
- Antiproliferative factor-induced changes in phosphorylation and palmitoylation of cytoskeleton-associated protein-4 regulate its nuclear translocation and DNA binding: Zacharias, D. A., Mullen, M., et al.; Int. J. Cell Biol. 2012, 150918 (2012), Abstract
- Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases: R.S. Kohler, et al.; Mol. Cell. Biol. 30, 4507 (2010), Application(s): WB using human cell lysates, Abstract — Full Text
- CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity: Karasawa, T., Wang, Q., et al.; Cell Death Dis. 1, e102 (2010), Abstract
- Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling: Planey, S. L., Keay, S. K., et al.; Mol. Biol. Cell 20, 1454 (2009), Abstract
- Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004), Abstract — Full Text
- Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment: D.R. Klopfenstein, et al.; J. Cell Biol. 153, 1287 (2001), Abstract — Full Text
- A novel direct interaction of endoplasmic reticulum with microtubules: D.R. Klopfenstein, et al.; EMBO J. 17, 6168 (1998), Abstract — Full Text
- The plasma cell associated antigen detectable by antibody VS38 is the p63 rough endoplasmic reticulum protein: A.H. Banham, et al.; J. Clin. Pathol. 50, 485 (1997), Application(s): Flow Cytometry, Abstract
- Reassessment of the subcellular localization of p63: A. Schweizer, et al.; J. Cell Sci. 108, 2477 (1995), Abstract — Full Text
- Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers: A. Schweizer, et al.; J. Cell Biol. 126, 25 (1994), Abstract — Full Text
- A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein: A. Schweizer, et al.; J. Cell Sci. 104, 685 (1993), Abstract — Full Text
- Characterization of a novel 63 kDa membrane protein. Implications for the organization of the ER-to-Golgi pathway: A. Schweizer, et al.; J. Cell Sci. 104, 671 (1993), Abstract — Full Text
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