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Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. Inhibits ubiquitin proteasome pathway in cell culture (IC50=1µM). It has been suggested that the natural product lactacystin acts as a precursor for clasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome. Inhibits cathepsin A. Leads to a reduction of adipogenesis. Induces neurite growth and inhibits cell cycle progression.
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RUO – Research Use Only |
|---|
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| CAS | 38966-21-1 |
|---|---|
| Couple Type | Inhibitor |
| Purity | ≥98% (TLC) |
| Alternative Name | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone |
|---|---|
| CAS | 7770-78-7 |
| Couple Type | Inhibitor |
| Purity | ≥97% (HPLC) |
| Alternative Name | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone |
|---|---|
| CAS | 20362-31-6 |
| Couple Type | Inhibitor |
| Purity | ≥95% (HPLC) |
| Alternative Name | EGCG, (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate) |
|---|---|
| CAS | 989-51-5 |
| Couple Type | Inhibitor |
| Purity | ≥98% (HPLC) |