CK-666

ALX-270-506

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Cell permeable inhibitor human (IC₅₀=4µM), fission yeast (IC₅₀=5µM), S. cerevisiae (IC₅₀=12µM) and bovine (IC₅₀=17µM) Arp2/3 complex between Arp2 and Arp3. Inhibits Listeria motility (IC₅₀=7µM).

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Product Details

Alternative Name	2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide
Appearance	White to tan-yellow solid.
CAS	442633-00-3
Couple Target	Arp
Couple Type	Inhibitor
Formula	C₁₈H₁₇FN₂O
MW	296.3
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (a minimum concentration of 5 mg/ml is recommended).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

ATG9B regulates bacterial internalization via actin rearrangement: Iibushi, J., Nozawa, T., et al.; iScience 27, 109623 (2024), Abstract
Two-step nuclear centring by competing microtubule- and actin-based mechanisms in 2-cell mouse embryos: Y. Ye & H.A. Homer; EMBO Rep. 23, e55251 (2022), Abstract
Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy: C.W. Hsieh, et al.; Nat. Commun. 10, 969 (2019), Application(s): added during cell culture to screen for functional and structrual changes in mitophagy in HeLa cells expressing EBFP-2-Parkin, EGFP-dMito and KillerRed-dMito, Abstract — Full Text
The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation: Nozawa, T., Aikawa, C., et al.; Autophagy 13, 1841 (2017), Abstract
Characterization of two classes of small molecule inhibitors of Arp2/3 complex: B.J. Nolen, et al.; Nature 460, 1031 (2009), Abstract

Last modified: May 29, 2024

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CK-666

ALX-270-506

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