Citrinin

BML-CM116

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MPTP activator

Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.

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Product Details

Appearance	Yellow crystalline solid.
CAS	518-75-2
Couple Target	MPTP
Couple Type	Activator
Formula	C₁₃H₁₄O₅
MW	250.2
Purity	≥98% (HPLC, TLC)
Solubility	Soluble in 100% ethanol, methylene chloride (10mg/ml), methanol, dioxane, pyridine or dichlormethane. Insoluble in water.
Source	Isolated from Penicillium citrinum

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts: W.H. Chan; Biochem. J. 404, 317 (2007), Abstract
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway: F.Y. Yu et al.; Toxicol. Lett. 161, 143 (2006), Abstract
Clin Microbiol Rev: J.W. Bennett & M. Klich; Clin. Microbiol. Rev. 16, 497 (2003), Abstract
Citrinin-induced mitochondrial permeability transition: E:J. Da Lozzo et al.; J Biochem Mol Toxicol 12, 291 (1998), Abstract
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling: G.M. Chagas et al.; J. Appl. Toxicol. 15, 91 (1995), Abstract

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Citrinin

BML-CM116

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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