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Antitumor agent
A potent platinum-based antineoplastic drug. Its mode of action involves formation of inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I. Cisplatin synergizes with a variety of anticancer agents. Tumor cells rapidly develop resistance to cisplatin and numerous agents are available to block or reverse resistance.
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Product Details
| Alternative Name |
cis-Platinum(ll)diamine dichloride |
|---|---|
| Appearance |
Off-white to orange powder. |
| CAS |
15663-27-1 |
| Formula |
Cl2H6N2Pt |
| MI |
14: 2317 |
| MW |
300.0 |
| Purity |
≥98% (HPLC) |
| RTECS |
TP2450000 |
| Solubility |
Soluble in dimethyl formamide (16mg/ml) or DMSO (10mg/ml); sparingly soluble in water; insoluble in 100% ethanol. |
| Technical Info / Product Notes |
In aqueous solution cis-trans isomerization of cisplatin occurs. Isomerization is increased at elevated temperatures. Stability of cisplatin in aqueous solutions was enhanced by increasing the sodium chloride (NaCl) concentration to 0.9% and was adversely affected in alkaline solutions such as sodium bicarbonate solutions. Further, even though soluble in DMSO we do not recommend to dissolve cisplatin in DMSO. The DMSO inserts itself into the ligand. It is recommended to prepare all solutions fresh and protect from light. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
Ambient |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Phosphorylation by JNK switches BRD4 functions: Devaiah, B. N., Singh, A. K., et al.; Mol. Cell 84, 4282 (2024), Abstract
- Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance: Overchuk, M., Rickard, B. P., et al.; Photochem. Photobiol. 100, 1676 (2024), Abstract
- Epigenetic reprogramming shapes the cellular landscape of schwannoma: John Liu, S., Casey-Clyde, T. J., et al.; Nat. Commun. 15, 476 (2024), Abstract
- LINC00261 expression reduces mutation accumulation while conferring resistance to cisplatin and altering the tumor-immune microenvironment in lung adenocarcinoma: Castillo, J., Xue, T., et al.; bioRxiv , (2023)
- Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape: R. Sinha, et al.; Cancers 15, 5204 (2023), Abstract
- IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling: J.H. Siamwala, et al.; Commun. Biol. 6, 1200 (2023), Abstract
- Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria: M. Ty, et al.; Sci. Transl. Med. 15, eadd9012 (2023), Abstract
- Relative refractoriness of breast cancer cells to tumour necrosis factor-α induced necroptosis: B. Thakur, et al.; Clin. Exp. Pharmacol. Physiol. 49, 1294 (2022), Abstract
- Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer: Chang, Y. C., Chang, P. M., et al.; Front. Oncol. 11, 811635 (2022), Application(s): In Vitro, Abstract
- Mass-Cytometry-Based Quantification of Global Histone Post-Translational Modifications at Single-Cell Resolution Across Peripheral Immune Cells in IBD: L. Bai, et al.; J. Crohns Colitis 17, 804 (2022), Abstract
- The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination: F. Wimmers, et al.; Cell 184, 3915 (2021), Abstract — Full Text
- Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells: D. Bloemberg & J. Quadilatero; J. Cell. Physiol. 236, 3099 (2021), Application(s): Mouse skeletal myoblasts (C2C12) treatment, Abstract
- Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells: Moustafa, D., Elwahed, M. R. A., et al.; PLoS One 16, e0235025 (2021), Abstract
- A selective p53 activator and anticancer agent to improve colorectal cancer therapy: H. Ramos, et al.; Cell Rep. 35, 10892 (2021), Abstract
- Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures: Y. Zhao, et al.; PLoS Negl. Trop. Dis. 14, e0008112 (2020), Abstract
- EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis: Fan, C. C., Tsai, S. T., et al.; Redox Biol. 34, 101571 (2020), Abstract
- Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation: Cetinkaya-Fisgin, A., Luan, X., et al.; Sci. Rep. 10, 21889 (2020), Abstract
- Natural killer cell phenotype is altered in HIV-exposed seronegative women: N.Q. Zhao, et al.; PLoS One 15, e0238347 (2020), Abstract — Full Text
- 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts: Liu, Y. C., Peng, B. R., et al.; Mar. Drugs 18, (2020), Abstract
- Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals: Klicznik, M. M., Morawski, P. A., et al.; Sci. Immunol. 4, (2019), Abstract
- Human CD4sup>+/sup>CD103sup>+/sup> cutaneous resident memory T cells are found in the circulation of healthy subjects: Klicznik, M. M., Morawski, P. A., et al.; bioRxiv , (2018)
- Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging: Cheung, P., Vallania, F., et al.; Cell 173, 1385 (2018), Abstract
- SATB1 and bladder cancer: Is there a functional link?: D. Choudhary, et al.; Urol. Oncol. 36, 9.30E+14 (2018), Abstract
- Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor: Kim, J., Shin, J. H., et al.; Oncotarget 8, 52345 (2017), Abstract
- Silver nanoparticles for the detection of cell surface antigens in mass cytometry: Schulz, A. R., Stanislawiak, S., et al.; Cytometry A 91, 25 (2017), Abstract
- Synthesis and characterization of a new alkyne functionalized bis(pyrazolyl)methane ligand and of its Pd(II) complexes: Evaluation of their in vitro cytotoxic activity: C. Di Nicola, et al.; Inorganica Chim. Acta 455, 677 (2017), Application(s): Cell culture
- Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment: J. Kim, et al.; J. Biomed. Sci. 24, 33 (2017), Abstract — Full Text
- Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure: D. Bloemberg, et al.; Data Brief 7, 1024 (2016), Application(s): Cell culture, Abstract
- Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize: Adams, S. R., Yang, H. C., et al.; Nat. Commun. 7, 13019 (2016), Abstract
- MicroRNA-Based Methods and Assays for Osteosarcoma: T. Ochiya, et al.; , (2016), (U. S. Patent)
- Exploiting Synthetic Lethality in Ovarian Cancer: R.L. O’Donnell; , (2016), (PhD thesis), Full Text
- Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673: A.Z. Andrei, et al.; Cancer Lett. 364, 8 (2015), Application(s): Cell Culture, Abstract
- Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry: Mei, H. E., Leipold, M. D., et al.; J. Immunol. 194, 2022 (2015), Abstract
- EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition: Zucal, C., D’Agostino, V. G., et al.; BMC Cancer 15, 855 (2015), Abstract
- Single Cell Mass Cytometry Reveals Remodeling of Human T Cell Phenotypes by Varicella Zoster Virus: N. Sen, et al.; Methods 90, 85 (2015), Application(s): Cell Culture, Abstract
- Cisplatin-induced renal injury is independently mediated by OCT2 and p53: Sprowl, J. A., Lancaster, C. S., et al.; Clin. Cancer Res. 20, 4026 (2014), Abstract
- CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells: Jia, J., Bosley, A. D., et al.; Cancer Res. 74, 2785 (2014), Abstract
- Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress: Eno, C. O., Zhao, G., et al.; Free Radic. Biol. Med. 65, 26 (2013), Abstract
- Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas?: Emdad, L., Qadeer, Z. A., et al.; Neuro Oncol. 13, 725 (2011), Abstract
- Protein kinase C inhibitor Go6976 augments caffeine-induced reversal of chemoresistance to cis-diamminedichloroplatinum-II (CDDP) in a human ovarian cancer model: L. Qamar, et al.; Gynecol. Oncol. 110, 425 (2008), Abstract
- Paclitaxel encapsulated in cationic liposomes increases tumor microvessel leakiness and improves therapeutic efficacy in combination with Cisplatin: S. Strieth, et al.; Clin. Cancer Res. 14, 4603 (2008), Abstract
- Effectiveness of hsp90 inhibitors as anti-cancer drugs: L. Xiao, et al.; Mini Rev. Med. Chem. 6, 1137 (2006), (Review), Abstract
- Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin: R.C. van Waardenburg et al.; J. Biol. Chem. 279, 54502 (2004), Abstract
- Cisplatin: mode of cytotoxic action and molecular basis of resistance: Z.H. Siddik; Oncogene 22, 7265 (2003), Abstract
- Biomolecular targets for platinum antitumor drugs: R.N. Bose; Mini Rev. Med. Chem. 2, 103 (2002), Abstract
- Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma: K. Seki, et al.; Cancer Chemother. Pharmacol. 45, 199 (2000), Abstract
- Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin: J. Melendez-Zajgla, et al.; Biochem. Mol. Biol. Int. 47, 765 (1999), Abstract
- The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage: J.G. Gong, et al.; Nature 399, 806 (1999), Abstract
- Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system: M.S. Razzaque, et al.; Histochem. Cell Biol. 111, 359 (1999), Abstract
- Cisplatin induces a persistent activation of JNK that is related to cell death: I. Sanchez-Perez, et al.; Oncogene 16, 533 (1998), Abstract
- Telomere loss in cells treated with cisplatin: T. Ishibashi & S.J. Lippard; PNAS 95, 4219 (1998), Abstract
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