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Ciprofloxacin . hydrochloride

ALX-380-288

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Fluoroquinolone antibacterial agent

Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Effective against Mycobacterium tuberculosis. Potentially anxiogenic.

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Product Details

Alternative Name	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride
Appearance	White to light yellow powder.
CAS	86393-32-0
Couple Target	DNA gyrase
Couple Type	Inhibitor
Formula	C₁₇H₁₈FN₃O₃ . HCl . H₂O
MI	14: 2314
MW	331.3 . 36.5 . 18.0
Purity	≥98% (HPLC)
Solubility	Soluble in water (35mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci: Mohammad, H., Younis, W., et al.; J. Med. Chem. 60, 2425 (2017), Abstract
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007), Abstract — Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J. 48, 1028 (2007), Abstract — Full Text
Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials: D.E. Nix & J.M. DeVito; Clin. Pharm. 6, 105 (1987), Abstract
Mechanisms of action of and resistance to ciprofloxacin: D.C. Hooper, et al.; Am. J. Med. 82, 12 (1987), Abstract
Is ciprofloxacin active against clinically important anaerobes?: B. Watt & F.V. Brown; J. Antimicrob. Chemother. 17, 605 (1986), Abstract

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Ciprofloxacin

ALX-380-287

Fluoroquinolone antibacterial agent

10 citations

Alternative Name	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid
CAS	85721-33-1
Couple Type	Inhibitor
Purity	≥98% (HPLC)

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Ciprofloxacin . hydrochloride

ALX-380-288

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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