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Ciprofloxacin

ALX-380-287

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Fluoroquinolone antibacterial agent

Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Effective against Mycobacterium tuberculosis. Potentially anxiogenic.

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Product Details

Alternative Name	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid
Appearance	White to light yellow crystalline powder
CAS	85721-33-1
Couple Target	DNA gyrase
Couple Type	Inhibitor
Formula	C₁₇H₁₈FN₃O₃
MI	14: 2314
MW	331.3
Purity	≥98% (HPLC)
RTECS	VB1993800
Solubility	Soluble in dilute hydrochloric acid; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Adaptations to cationic biocide exposure differentially influence virulence factors and pathogenicity in Pseudomonas aeruginosa: Vargas-Cuebas, G. G., Sanchez, C. A., et al.; Virulence 15, 2397503 (2024), Abstract
Evaluating the Efficacy of Eravacycline and Omadacycline against Extensively Drug-Resistant Acinetobacter baumannii Patient Isolates: M.S. Deolankar, et al.; Antibiotics 11, 1298 (2022), Abstract
Detection of microbial surface contamination and antibiotic resistant Escherichia coli on beef carcasses in Arusha, Tanzania: R. Murutu, et al.; Afr. J. Microbiol. Res. 10, 1148 (2016), Application(s): Determining antibiotic susceptibility, E. coli isolates, Full Text
In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates: A. AbdelKhalek, et al.; PLoS One 11, e0164227 (2016), Application(s): In vitro antibacterial activity of rhodanine compounds 1 to 7 against Bacillus anthracis, Abstract — Full Text
Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION: Mudeppa, D. G., Kumar, S., et al.; J. Biol. Chem. 290, 20313 (2015), Abstract
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007), Abstract — Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J. 48, 1028 (2007), Abstract — Full Text
Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials: D.E. Nix & J.M DeVito; Clin. Pharm. 6, 105 (1987), Abstract
Mechanisms of action of and resistance to ciprofloxacin: D.C. Hooper, et al.; Am. J. Med. 82, 12 (1987), Abstract
Is ciprofloxacin active against clinically important anaerobes?: B. Watt & F.V. Brown; J. Antimicrob. Chemother. 17, 605 (1986), Abstract

Related Products

Ciprofloxacin . hydrochloride

ALX-380-288

Fluoroquinolone antibacterial agent

6 citations

Alternative Name	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride
CAS	86393-32-0
Couple Type	Inhibitor
Purity	≥98% (HPLC)

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Ciprofloxacin

ALX-380-287

Product Details

Handling & Storage

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