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Ciprofibrate

ALX-270-475

4 citations

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PPARα activator

Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist.

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Product Details

Alternative Name	2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
Appearance	White to light yellow powder.
CAS	52214-84-3
Couple Target	PPAR
Couple Type	Activator, Ligand
Formula	C₁₃H₁₄Cl₂O₃
MI	14: 2313
MW	289.2
Purity	≥98% (HPLC)
RTECS	UF0880000
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

P450 CYP2C epoxygenase and CYP4A ω-hydroxylase mediate ciprofibrate-induced PPARα-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007), Abstract — Full Text
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005), Abstract
Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999), Abstract
Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999), Abstract

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Ciprofibrate

ALX-270-475

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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