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Cinnamtannin B-1

ALX-350-365

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Potent antioxidant

A-type proanthocyanidin contained in several plant species such as Laurus nobilis L. , Vaccinium vitis-idaea, Parameria laevigata, Cinnamomum zeylanicum, Lindera umbellata, Metaxya rostrata. Potent antioxidant, TEAC method (nM Trolox) = 0.95. Protective agent against oxidative stress and apoptosis in human platelets.
Inhibitory activity against cyclooxygenase-2 (COX-2) in vitro.
DPPH radical scavenging IC₅₀ 6.14µM
Lipid peroxidation inhibition 159.74
Nitric oxide inhibition 10.28
Antibacterial against B.subtilis (9mm, 20mg/ml)

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Product Details

Alternative Name	Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin
Appearance	Brown solid.
CAS	88082-60-4
Couple Target	COX
Couple Type	Inhibitor
Formula	C₄₅H₃₆O₁₈
Identity	Determined by 1H-NMR.
MW	864.7
Purity	≥95% (HPLC)
Solubility	Soluble in 100% ethanol, methanol or in a mixture of DMSO and water.
Source	Isolated from Laurus nobilis L.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Ethanol reduces kainate-evoked glutamate secretion in rat hippocampal astrocytes: P. Santofimia-Castano, et al.; Brain Res. 1402, 1 (2011), Abstract
Bioactive A-Type Proanthocyanidins from Cinnamomum cassia: K.B. Killday, et al.; J. Nat. Prod. 74, 1833 (2011), Abstract
Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties: T.O. Idowu, et al.; Phytochemistry 71, 2092 (2010), Abstract
Increased calcium influx in the presence of ethanol in mouse pancreatic acinar cells: A. Del Castillo-Vaquero, et al.; Int. J. Exp. Pathol. 91, 114 (2010), Abstract
Effect of cinnamtannin B-1 on CCK-8-evoked responses in mouse pancreatic acinar cells: R. Rivera-Barreno, et al.; Clin. Exp. Pharmacol. Physiol. 37, 980 (2010), Abstract
Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells: M. Fernandez-Sanchez, et al.; BMC Cell Biol. 10, 77 (2009), Abstract
Phytochemical Composition and Antioxidant Activity of Laurus nobilis L. Leaf Infusion: S. Dall’Acqua, et al.; J. Med. Food 12, 869 (2009), Abstract
Chemical and Pharmacological Investigations of Metaxya rostrata: J. Wirtbauer, et al.; Z. Naturforsch. 63, 465 (2008), Abstract
Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor: J.J. López, et al.; Life Sciences 82, 977 (2008), Abstract
Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys. 457, 235 (2007), Abstract

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Cinnamtannin B-1

ALX-350-365

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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