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Cilostamide

BML-PD125

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PDE inhibitor

Phosphodiesterase PDE3 inhibitor (IC₅₀=5 nM). Blocks PKB/Akt signaling pathway by inhibition of Akt-activated PDE3B. Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.

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Product Details

Alternative Name	OCP 3689, OPS 3689, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
Appearance	White to off-white solid.
CAS	68550-75-4
Couple Target	PDE
Couple Type	Inhibitor
Formula	C₂₀H₂₆N₂O₃
Identity	Determined by NMR.
MW	342.4
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light and oxygen. Packaged under inert gas.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Skeletal muscle derived Musclin protects the heart during pathological overload: Szaroszyk, M., Kattih, B., et al.; Nat. Commun. 13, 149 (2022), Abstract
Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper): Y. Pang & P. Thomas; Gen. Comp. Endocrinol. 265, 180 (2018), Abstract
Immature Oocytes from Unprimed Juvenile Mice Become a Valuable Source for Embryo Production When Using C-Type Natriuretic Peptide as Essential Component of Culture Medium: S. Romero, et al.; Biol. Reprod. 95, 64 (2016), Application(s): Comparative developmental capacity of oocytes undergoing Pre-IVM in presence of CNP or an inhibitor of phosphodiesterase type 3 (PDE3-I), Abstract — Full Text
Cilostamide and forskolin treatment during pre-IVM improves preimplantation development of cloned embryos by influencing meiotic progression and gap junction communication in pigs: B. Park, et al.; Theriogenology 86, 757 (2016), Abstract
Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation: M. Shelly, et al.; Science 327, 547 (2010), Abstract
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding: A.Z. Zhao, et al.; Nat. Neurosci. 5, 727 (2002), Abstract
Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells: F. Ahmad, et al.; J. Immunol. 164, 4678 (2000), Abstract
Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes: C.B. Andersen, et al.; J. Biol. Chem. 273, 18705 (1998), Abstract
Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase–basic and potential clinical applications: H. Hidaka & T. Endo; Adv. Cyclic Nucleotide Protein Phosphorylation Res. 16, 245 (1984), Abstract

Last modified: May 29, 2024

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Cilostamide

BML-PD125

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