Phosphodiesterase PDE3 inhibitor (IC50=5 nM). Blocks PKB/Akt signaling pathway by inhibition of Akt-activated PDE3B. Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.
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RUO – Research Use Only |
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