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Ciglitazone

BML-GR205

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PPAR ligand

Ciglitazone is a thiazolidinedione type of antihyperglycemic agent. It displays antihyperglycemic activity in genetically obese C57 Bl/6 ob/ob mice and is a selective PPARγ agonist (EC₅₀=3 µM). Inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells.

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Product Details

Appearance	White to off-white.
CAS	74772-77-3
Couple Target	PPAR
Couple Type	Ligand
Formula	C₁₈H₂₃NO₃S
Identity	Determined by NMR.
MW	333.5
Purity	≥98% (HPLC)
RTECS	XJ5813700
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Systemic PPARgamma ligation inhibits allergic immune response in the skin: Dahten, A., Koch, C., et al.; J. Invest. Dermatol. 128, 2211 (2008), Abstract
Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression: Han, S., Sidell, N., et al.; Int. J. Cancer 111, 322 (2004), Abstract
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses: R.B. Clark, et al.; J. Immunol. 164, 1364 (2000), Abstract
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999), Abstract
Thiazolidinediones–the new insulin enhancers: R.J. Jha; Clin. Exp. Hypertens. 21, 157 (1999), Abstract
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells: B. Lohrke, et al.; J. Endocrinol. 159, 429 (1998), Abstract
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996), Abstract
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994), Abstract

Last modified: May 29, 2024

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Ciglitazone

BML-GR205

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