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Chromomycin A3

BML-GR302

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Transcription inhibitor

Chromomycin A₃ is a GC-specific DNA ligand which inhibits transcription. It may be used as a fluorescent DNA stain. Antibiotic. Cell permeable fluorescent dye that cann be used with Bisbenzimide H33258 to distinguish chromosomes by their total DNA concentration and their DNA base composition. Does not intercalate. Ex(max): 445nm; Em(max): 575nm

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Product Details

Appearance	Yellow solid.
CAS	7059-24-7
Couple Target	DNA
Couple Type	Ligand
Formula	C₅₇H₈₂O₂₆
MW	1183.3
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol, DMSO or ethyl acetate (10mg/ml)
Source	Isolated from Streptomyces griseus

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells: S. Wong, et al.; Biochem. Pharmacol. 47, 827 (1994), Abstract
Selective accumulation of diamidino yellow and chromomycin A3 by retinal glial cells: C.-J. Jeon & R.H. Masland; J. Histochem. Cytochem. 41, 1651 (1993), Abstract
Specific staining of DNA with the fluorescent antibiotics, mithramycin, chromomycin, and olivomycin: H.A. Crissman & R.A. Tobey; Methods. Cell Biol. 33, 97 (1990), Abstract
Chromomycin A3 and its derivatives: K. Mizuno; J. Antibiot. 16, 22 (1963)

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Chromomycin A3

BML-GR302

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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