Chroman 1

• GMP format available

Chroman 1 is a highly potent and selective inhibitor of Rho-associated kinase 2 (ROCK2). It exhibits an IC50 value of less than 1 nM for ROCK2, making it significantly more potent against ROCK2 compared to ROCK1 (IC50 = 52 pM) and MRCKα (IC50 = 150 nM). This makes it a valuable tool for investigating cell signaling pathways, particularly those involving cytoskeletal dynamics and cell motility.

ROCK2 inhibitors like Chroman 1 are being explored for their potential therapeutic applications in diseases such as:

• Cardiovascular Diseases: Due to its role in vascular smooth muscle contraction and endothelial function.
• Neurodegenerative Diseases: Given its involvement in neuronal survival and axon regeneration.
• Cancer: For its potential to inhibit tumor cell invasion and metastasis

Key features and applications include:

• Research Tool: Used to study the role of ROCK2 in cellular processes due to its high potency (i.e., IC50 < 1 nM for ROCK2) and selectivity (i.e., greater selectivity for ROCK2 over other kinases like PKA and MRCKα).
• Cell Signaling Pathways: Investigates pathways involving cytoskeletal dynamics and cell motility.